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Olanzapine - Drug Details

Olanzapine (Zyprexa)

Classification

Atypical antipsychotic

Mechanism of Action

Indications

Schizophrenia, bipolar disorder

Dosage and Administration

5-20 mg orally once daily

Forms

Tablets, orally disintegrating tablets

Side Effects

Weight gain, drowsiness, increased appetite

Contraindications

Severe liver impairment, known hypersensitivity

Interactions

Caution with other CNS depressants

Precautions

Monitor for signs of metabolic syndrome

Pharmacokinetics

Half-life: 21-54 hours, metabolized in the liver

Pharmacodynamics

Modulates neurotransmitter pathways in the brain

Storage Requirements

Store at room temperature, protect from light

Patient Counselling

Counsel on the risk of weight gain and metabolic changes